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Indahnya Kesuksesan & Kebahagian Bersama Allah SWT Author : Sri Astuti, Astuti Abstrak: Download disini !  

Nitroglycerin is a drug of choice in the treatment of angina pectoris. Commonly used as buccal, sublingual
and injection. Sublingual treatment cause discomfort and sensation burning on its use. In this research used
forms microemulsion transdermal. Transdermal offers a way alternatives for the delivery of nitroglycerin
without passing through the intestines, so it is more convenient and safe for long term use. Microemulsion is
expected to increase the penetration of the drug because contains high concentrations of surfactants. This
research aims to determine the effect of the active agent nitroglycerin into microemulsion system and see its
physical stability and to obtain the best formulation. Used three variations of the concentration of tween 80,
there is 40%, 42.5% and 45%. Stability testing of physical properties during 8 weeks. From the results of
evaluation data showed that Formula 2 is the best formula with the result, among others, as The following pH
of 5.69 ± 0.01, the viscosity of 1480.26 ± 2.83 Cps, Specific Gravity of 1.0723 ± 0.00011 g / mL, Surface
Tension of 38.52 ± 0.037 dyne / cm and particle size of 77.95 nm.
Keywords: Tween 80, Mikroemulsi, Nitroglycerine, Transdermal

Carvedilol is widely prescribed for long-term hypertension treatment. It is rapidly absorbable by
oral administration, but its bioavailability is merely about 20% in humans. Drug delivery is therefore
imperative to overcome this weakness. One form of transdermal drug delivery system is a patch.
Transdermal patch is composed of various systems, for instance, a reservoir that uses a rate control
layer to manage the rate of drug release. This research aimed to observe the effect of using resin gum
as the control of drug release rate on the physical characteristics and release of carvedilol in a
transdermal patch. The patches were prepared in 5 formulas with different quantities of resin gum,
namely 50, 100, 150, 200, and 250 mg. Afterward, they were evaluated physically, and their
dissolution and diffusion rates were analyzed. The results showed that resin gum with concentrations
of 150 mg and 200 mg was physically qualified for rate control. Besides, the results of dissolution and
diffusion tests revealed that transdermal patches with 150 mg of resin gum exhibited the best drug
release and penetration.

Buah naga selain dikonsumsi dalam bentuk segar juga diolah menjadi beberapa produk
olahan. Kulit buah naga mengandung pektin ±10,8%. Pada industri farmasi dan
makanan, pektin digunakan sebagai pengikat, pembentuk gel, penstabil, dan pengental.
Penelitian ini bertujuan untuk mengisolasi pektin, mengkarakterisasi pektin dan
mengetahui pengaruh perbedaan konsentrasi pektin sebagai bahan pengikat terhadap
viskositas yang dihasilkan pada sediaan pasta gigi. Pektin yang dihasilkan dianalisa
secara kualitatif menggunakan FTIR dan memenuhi persyaratan JEFCA ( Joint Expert
Committee for Food Additives (FAO/WHO)) dengan nilai susut pengeringan 11,03%,
kadar abu 0,41 %, berat ekivalen 617,29 mg dan kadar metoksi 6,50% . Pektin yang
sudah dikarakterisasi dibuat pasta gigi dalam 4 formula dengan konsentrasi pektin
sebesar 3%, 3,5%, 4% dan 4,5%, kemudian dievaluasi sifat fisiknya meliputi
organoleptis, homogenitas, pH, viskositas dan sifat alir. Dari hasil penelitian
menunjukkan bahwa semakin meningkat konsentrasi penggunaan pektin kulit buah naga
maka semakin besar pula viskositas yang dihasilkan.

Faculty of Pharmacy and Science, University of Muhammadiyah Prof. Dr. Hamka, Jakarta, Indonesia
Palm oil is one of the fatty oil can used as the oil phase in the microemulsion system. The purpose of this
research was to identify the effect of increasing concentration of combination of surfactant and cosurfactant on
the physical stability of palm oil microemulsion. This oil was formulated into microemulsion system by increas
ing concentration of combination of tween 80 and sorbitol (1:1) in various concentrations, which were 54%,
56%, 58% and 60% as surfactant and cosurfactant component. The evaluation included organoleptic, viscosity
test, pH, density, surface tension and particle size and zeta potential test. The pH showed in the range 5.8
to 6.4. Viscosity value obtained between 637.47 to 808.20 Cps. Density measurement were between 1.1123 to
1.1235 g/ml. The results of surface tension obtained between 39.76 to 43.07 dynes/cm. The results of particle
size measurement results obtained from 21.27 to 23.97 nm and the zeta potential between −10.28 to −18.03.
It can be concluded that the increasing of concentration of surfactant and cosurfactant can improve physical
stability of the microemulsion.

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