Curcumin encapsulation using dendrimer PAMAM G4 conjugated with polyethylene glycol to improve the properties of gel dossage form

Curcumin had a low bioavailability, to improve it than curcumin was encapsulated in the PAMAM dendrimer conjugated PEG. To facilitate topical use, curcumin dendrimer was combined with a carbomer 940 that can produce hydration conditions in the stratum corneum so as to increase the bioavailability of curcumin. This study aimed to obtain the ratio between curcumin with dendrimer of PAMAM G4: PEG in the formation of curcumin dendrimer combined in the base of carbomer 940 to produce the optimal of physical characteristics of dendrimer and physical stability of gel. The study was conducted by conjugating PAMAM G4 with PEG with a ratio of 1:5, and then encapsulated curcumin in dendrimer with a ratio of 1:0.2 (F1); 1:0.02 (F2) and 1:0.002 (F3). Further dendrimers that have encapsulated curcumin were formulated in a gel with a carbopol base 940. The physical characteristics of the gel tested were polydispersity index, zeta potential and particle size, organoleptic, flow properties, and pH at weeks 0, 2, 4 and 6. The results shows that F1 has zeta potential highest and the lowest viscosity of the other formula, while F3 has the lowest potential zeta and highest viscosity of other formulas. In addition, the polydispersity index, particle size, organoleptic, flow properties and pH; there are not a significant difference in each formula, but the particle size, zeta potential, and viscosity of gel can decrease with longer storage time. Conclusion of this study that the ratio between curcumin and dendrimer PAMAM G4:PEG of 1: 0.2 shows the optimal of physical characteristics of dendrimer and physical stability of gel.

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Optimization Online Analytical Processing (OLAP) Data Sales Door Case Study CV Adilia Lestari

Sales transaction data in the sales division related to sales data goods so large and
many that require large storage media and difficult to process these data for the preparation
of reports used by management for decision making. Online Analitycal Processing (OLAP)
is a method of approach to present the answers to the demand for a rapidly dimensional
analysis process, ie the design of applications and technologies that can collect, store,
manipulate a multidimensional data for analyst purposes. OLAP is part of a more global
category of business thinking, which also summarizes the relationship between reporting
and data mining. Use of this prototype helps executive informations system in generating
monthly goods sales report that is 0,022259399998 sec, sales report top 10 that is
0,0223899998998 second, sales report down 10 that is 0,0210279999301 second, report
sales by province that is 0,0399869999535 second, report Sales by district are
0.0133039000143 seconds. So it can help generate reports faster sales data and compliance
report generated from the resulting prototype has in common with the existing report
format so that the prototype is right in generating the report. OLAP technology can
facilitate stakeholders in making decisions based on existing transactional data because
OLAP will display data from various sides or multidimens.

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PENINGKATAN HASIL BELAJAR IPA melalui pendekatan CONTEXTUAL teaching AND learning (CTL) pada murid kelas V SDN GUNUNG SARI II RAPPOCINI MAKASSAR

Penelitian ini merupakan penelitian tindakan kelas (classroom action researsh) yang bertujuan untuk meningkatkan hasil belajar IPA murid kelas V SDN Gunung Sari II Rappocini Makassar. Tindakan yang diterapkan adalah pendekatan Contextual Teaching and Learning (CTL) untuk materi pembelajaran Sistem Pencernaan Makanan Pada Manusia.

Subjek penelitian adalah murid kelas V SDN Gunung Sari II Rappocini Makassar yang berjumlah 27 orang. Penelitian ini dilaksanakan selama 2 bulan, mulai bulan Agustus 2010 sampai bulan Oktober 2010.

Proses pengumpulan data diperoleh melalui observasi dan “tes hasil belajar. Observasi dilakukan untuk mengamati proses penerapan pendekatan Contextual Teaching and Learning (CTL) dalam pembelajaran IPA di kelas, sedangkan tes hasil belajar digunakan untuk mengukur hasil belajar murid setelah diterapkan pendekatan Contextual Teaching and Learning (CTL).

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ESTIMASI KERUGIAN EKONOMI AKIBAT GIZI BURUK PADA BALITA DI BERBAGAI KABUPATEN/KOTA DI LUAR PULAU JAWA DAN BALI

The purpose of this study was to estimate economic lost due to severe underweight amongunderfve children in various cities/regencies outside Java and Bali Islands. A bundle of secondarydata, namely: nutritional status of underfve children from 2007 Riskesdas, demographic data,GDRP (Gross Domestic Regional Product), and poverty level are gathered and analyzed toelaborate the study objectives. All of 314 cities/regencies at outside of Java and Bali Island weretreated as sample of this study. Data processing and analysis were conducted in Bogor, from Mayto July 2010. The study show that the higher poverty level, the higher the prevalence of severeunderweight. On the other hand, the higher the GDRP per capita the lower the prevalence ofsevere underweight. The study showed that economic lost due to severe among underfve childrenin outside Java and Bali Islands was ranged from 0,1% GDRP to 0,45% GDRP (r = 5%) andwas ranged from 0,11% GDRP to 0,51% GDRP (r = 10%). The highest economic lost due tosevere underweight was found in District of Mimika, Papua, and the lowest was Tomohon City,North Sulawesi.

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