Modul Mata Pelajaran Sejarah SMA Kelas XI Author : Gunawan, Rudy Abstrak: Download disini !
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Author : Abstrak: Download disini !
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Author : Haryati, Iis Abstrak: Download disini !
In Silico Study of Pyrazolylaminoquinazoline Toxicity by Lazar, Protox, and Admet Predictor
Pyrazolylaminoquinazoline is obtained from synthetic AZD4547 and can inhibit kinase activity in recombinant
fibroblast growth factor receptor (FGFR) in vitro. The objective of this study was to obtain high activity and low
toxicity pyrazolylaminoquinazoline derivatives in silico. The 2-dimensional structures were generated using the
ChemDraw application. The Lazar application was used to predict endpoint carcinogenicity, maximum daily dose,
and mutagenicity. The ProTox application was used for endpoint LD50 and toxicity classes, while the ADMET
application was used for endpoint hepatotoxicity, with reproductive system disorders, and endocrine. Based on the
scoring from the three software applications, two compounds were identified as being active against FGFR 2, with no
carcinogenic or toxic effects on the liver, endocrine system, and the reproductive system, but they were predicted to
have mutagenic effects. These compounds were V29 (N-(5-(3,5-dimethoxy phenethyl -1H-pyrazol-3-yl)-7(octahydro-
2H-pyrido[1,2-a]pyrazine-2-yl) quinazoline-4-amine), with an IC50 of 0.2 ± 0.1 nM and a toxicity score of 1027, and
V32 (N-(5-(3,5-dimethoxy phenethyl)-1H-pyrazol-3-yl)-7-(4-(dimethylamino)piperidine-1-yl)quinazoline-4-amine),
with an IC50 of 0.3 ± 0.1 nM and a toxicity score of 1024.
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Author : Yeni, Yeni Abstrak: Download disini !
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Author : Abstrak: Download disini !
Human Integration of a Character-based Curriculum and Humanistic Values As Basic Initiation of a Human Rights-friendly School
A Human Rights-Friendly School is founded where human rights are learned, taught,
practiced, respected, protected, and promoted. A qualitative approach was taken
and the study used thematic analysis of key concepts and codes. The study aims
to build the capacity of the whole school community by promoting a democratic
environment, innovative teaching methods, and responsible citizenship. From the
way decisions are made in schools, to the way people treat each other, to the
curriculum and extracurricular activities on offer, right down to the very surroundings
in which students are taught, the school becomes an exemplary model for human
rights education.
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Author : Nadjib, Mardiati Abstrak: Download disini !
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Author : Fitriani, Somariah Abstrak: Download disini !
PURIFIKASI DAN MODERNISASI DI MUHAMMADIYAH RANTING ULUJAMI JAKARTA SELATAN
This research studied on purification and modernization of Muhammadiyah in
the Ranting Ulujami, South Jakarta. This research is conducted through
qualitative method combining three data collection techniques; review on
documents (books and journal articles), interview, and observation. This
research reveals that purification and modernization as the main character of
Muhammadiyah, are performed by its branch in the Ranting Ulujami. Regarding
the purification of aspect of worship (mahdhoh), the Muhammadiyah leaders in
the Ranting emphasize the need to strongly hold the hadith shohih and reject the
hadith dhoif. Innovation in worship, for these leaders, is bid’ah. However, the
implementation of the purification has been negotiated with the local religious
tradition that has been long established in Ulujami. Tahlilan, a religious
ceremony during the death of family, is an example. The Muhammadiyah in
Ulujami negotiate it by producing new kind of tahlilan, or constructing new
meaning of the tahlilan to prevent them from “cultural or religious clash” within
the society. Meanwhile the modernization of social aspect is perceived by the
leaders of Muhammadiyah in Ranting Ulujami as social piety. For them, a
Muslim can be categorized as modern when he/she is not only concerned on their
individual piety such as praying and reading the Qur’an, but also enthusiastic in
implementing Islamic values related to public good.