Category: Repository

Author : Abstrak: Download disini !  

Author : Hadi Sunaryo, Hadi Abstrak: Download disini !  

Author : Sari Nurlaily, Sari Abstrak: Download disini !  

The combination of ginger (Zingiber officinale Rose.,) extract and zinc has the effect of lowering levels of glucose, triglycerides, cholesterol and anti-oxidants. This study aimed to determine the safety administration of combination ginger extract and zinc, through subchronic toxicity test. Parameters measured were body weight, liver and kidney histopathology. SGOT. and SGPT The study used a sample of 20 male mice, divided into one control group and one treatment group. The extract was given orally through a sonde for 75 days. The treatment group were given a combination of ginger extract and zinc (ginger 30mg / 20g BW + zinc 0.4mg / 20g BW ) and control group was given a water. After 75 days of treatment sample blood the heart and then checked SGOT and SGPT. Collected statistical from result with the method of independent samples T test showed no significant difference between the levels of SGOT ang SGPT control group to the treatment group. It can be concluded combination ginger extract and zinc did not show any toxic effects in subchronic and did not cause toxicity and damage to vital organs, such as liver and kidney.

Author : Abstrak: Download disini !  

Author : Hadi Sunaryo, Hadi Abstrak: Download disini !  

Drug Related Problems (DRPs) are unwanted incidence that happen to patients associated with drug therapy. Among the categories of DRPs are incorrect drug selection and dmg interactions, which are often found in common patients who have the disease, such as type 2 diabetes mellitus. This study aimed to determine the incidence of DRPs with category of incorrect dmg selection and dmg interactions in patients with type 2 diabetes mellitus in Gatot Subroto Army Central Hospital Jakarta. This research was conducted with non-experimental descriptive design and data acquisition retrospectively for medical record data.

The patient’s criteria as subject in this study were inpatient in Gatot Subroto Army Central Hospital in Jakarta, diagnosed with type-2 diabetes mellitus. have no pregnancy during the study, receive diabetes mellitus medications, and have complete medical record data. The data were analyzed descriptively. The results showed there were 42 patients diagnosed with diabetes mellitus type 2 in which 50% of men and 50% of women, with aged 40-60 years 64.29% and > 61 years 35.71%. Single hypoglycemic drugs most widely used class of short-acting insulin as much as 83.3%. hypoglycemic dmg combination is the most widely used short-acting insulin + long-acting insulin as much as 54.76%. From 42 patients. 12 patients (28.57%) experienced DRPs with category of incorrect dmg selection including the used of unsafe drugs 19.05%. incorrect drugs 7.14%. and dmg combinations that are not necessary 2.38 %. On DRPs with category of dmg interactions, patients can receive more than one drug interactions. From 42 patients observed 112 dmg interactions, there were 47 (41.96%) cases were interaction between sullonylurea with other dmgs. cause increasing effect of sulfonylurea dmgs that pose an increased risk of hypoglycemic. 29 (69.05%) cases were interaction between sulfonylurea with other dmgs caused decreased effect sulfonylurea and 36 (32.14%) cases were interaction between metformin with other dmgs caused increasing the risk of hypoglycemic effect.

Author : Muhammad Zaki Sopiani, Zaki Abstrak: Download disini !  

Daun kelor merupakan tanaman yang sering digunakan sebagai penurun kadar
kolesterol. Tujuan penelitian ini untuk membuktikan pengaruh pemberian fraksi etil
asetat ekstrak daun kelor terhadap penurunan kadar kolesterol total dan LDL darah pada
hamster hiperkolesterolemia. Penelitian ini menggunakan hamster Syrian jantan yang
dibagi dalam 6 kelompok perlakuan, masing-masing terdiri 4 hamster: kelompok I
(kontrol normal), kelompok II (kontrol positif) yang diberi atorvastatin, kelompok III
(kontrol negatif), kelompok IV, V, dan VI (kelompok uji) diberi fraksi etil asetat daun
kelor dengan dosis 1,186 mg/kg BB; 3,722 mg/kg BB; dan 7,444 mg/kg BB. Induksi pakan
tinggi kolesterol dengan kuning telur 10% dan pakan standar 90% diberikan selama 28
hari. Uji ANOVA satu arah (p<0,05) menunjukkan adanya pengaruh perlakuan. Uji LSD kolesterol total dan LDL menunjukkan kelompok VI dosis 7,444 mg/kg BB memberikan efek yang sama dengan kontrol positif yaitu atorvastatin dosis 5,2 mg/kg BB, sehingga disimpulkan dosis tersebut dapat menurunkan kadar kolesterol total dan LDL.

Author : Siska, Siska Abstrak: Download disini !