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AKTIVITAS ANTIHIPERTRIGLISERIDA DAN ANTIHIPERGLIKEMIK EKSTRAK DAUN KELOR (Moringa oleifera Lam.) PADA TIKUS HIPERTRIGLISERIDA DIABETES

Gaya hidup yang tidak sehat (obesitas) menjadi pemicu utama meningkatnya
prevalensi diabetes mellitus dan aterosklerosis atau bahkan komplikasi keduanya.
Tujuan penelitian ini untuk mengetahui bagaimana pengaruh pemberian ekstrak
etanol 70% daun kelor (Moringa oleifera Lam.) terhadap penurunan kadar
trigliserida dan glukosa darah pada tikus putih hipertrigliseridemia dan diabetes.
Penelitian ini menggunakan 30 ekor tikus yang dibagi menjadi 6 kelompok.
Sebagai bahan pembanding digunakan Fenofibrat dengan dosis 9 mg/KgBB dan
Glibenklamid dosis 0,9 mg/KgBB. Bahan uji diberikan selama 21 hari
menggunakan 3 variasi dosis, yaitu 150 mg, 300 mg dan 600 mg/KgBB.
Berdasarkan hasil uji analisa statistik ANOVA satu arah disimpulkan bahwa dosis
300 mg/KgBB dan dosis 600 mg/KgBB mempunyai aktivitas yang sama dalam
menurunkan kadar trigliserida darah dibandingkan dengan kontrol positif
Fenofibrat dosis 9 mg/KgBB. Sedangkan ekstrak etanol 70% daun kelor dosis 150
mg/KgBB, 300 mg/KgBB dan 600 mg/KgBB mempunyai kemampuan
menurunkan kadar glukosa darah tikus yang diinduksi aloksan dan pakan tinggi
trigliserida sebanding dengan Glibenklamid dosis 0,9 mg/Kgbb.

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Author : Zaimil Islam, Zaimil Abstrak: Download disini !  

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COMBINATION OF GINGER EXTRACT (Zingiber officinale Roscoe) AND ZINC AS METABOLIC SYNDROME IN HIGH CHOLESTEROL DIET DIABETIC MICE

Metabolic syndrome including the presence of obesity, insulin resistance and dyslipidemia that predisposes type 2 diabetes. The puipose of this study to prove the effectiveness of the combination of the ethanol extract of ginger (Zingiber officinale Roscoe) with Zinc (Zn) as a hypolipidemia, and hypoglycemia through the measurement of oxidized LDL, total cholesterol, triglycerides in diabetic mice fed high-cholesterol diet. This study used 54 male mice were divided into 9 groups: normal control group, negative control, positive control, ginger extract (ZO) group dose of 37.5 mg/kg, Zn 20 mg/kg and five groups with a test dose variation that ginger dose 1 (37.5 mg/kg) + Zn 20 mg/kg, ginger dose 2 (75 mg/kg) + Zn 20 mg/kg, ginger dose 3(150 mg/kg) + Zn 20 mg/kg of each test group given the extract for 14 days. Animal models used were mice induced by streptozotocin (STZ) and feed hypercholesterolemia. The results obtained from this study, combined with ginger extract 75 mg/kg and zinc 20 mg/kg can lower blood glucose levels by 39.87 %, comparable to metformin (p > 0.05). The combination of ginger extract 75 mg/kg with zinc 20 mg/kg can lower total cholesterol 65.88%, LDL cholesterol 74.62% and triglyceride levels 55.41%, comparable to atorvastatin (p > 0.05). The addition of Zn to ginger (ZO) extract can increase hypolipidemia activity and hypoglycemic activity of ginger extract.

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