Tag: jakarta

The 1-phenyl-1-(quinazolin-4-yl) ethanol compounds are alkaloids of quinozoline class found in many Hydrangeaceae families. A survey revealed that most of the identified quinazoline derivatives have anticancer activity. Toxicity prediction of 1-phenyl-1-(quinazolin-4-yl) ethanols compounds were performed to obtain the best three compounds with high activity and the lowest toxicity. Toxicity prediction was conducted using Toxtree, pkCSM and PreADMET. The 2D structure of compounds were formed using ChemDraw. The decision tree approach was used in Toxtree application with endpoints including Cramer rules, Kroes TTC, carcinogenicity (genotoxic and non genotoxic) and in vitro mutagenicity. Graph based signature was used in pkCSM application with endpoints including mutagenicity, maximum daily dose, LD50 and hepatotoxicity. In PreADMET application, a method based on drugs similarity and ADMET properties was used with endpoints including mutagenicity, carcinogenicity to rat and mice. The results of data analysis showed that the best three anticancer compounds that have high activity and the lowest toxicity are compounds 14, 16 and 19.

The 1-phenyl-1-(quinazolin-4-yl) ethanol compounds are alkaloids of quinozoline class found in many Hydrangeaceae families. A survey revealed that most of the identified quinazoline derivatives have anticancer activity. Toxicity prediction of 1-phenyl-1-(quinazolin-4-yl) ethanols compounds were performed to obtain the best three compounds with high activity and the lowest toxicity. Toxicity prediction was conducted using Toxtree, pkCSM and PreADMET. The 2D structure of compounds were formed using ChemDraw. The decision tree approach was used in Toxtree application with endpoints including Cramer rules, Kroes TTC, carcinogenicity (genotoxic and non genotoxic) and in vitro mutagenicity. Graph based signature was used in pkCSM application with endpoints including mutagenicity, maximum daily dose, LD50 and hepatotoxicity. In PreADMET application, a method based on drugs similarity and ADMET properties was used with endpoints including mutagenicity, carcinogenicity to rat and mice. The results of data analysis showed that the best three anticancer compounds that have high activity and the lowest toxicity are compounds 14, 16 and 19.

Peningkatan serapan kopi oleh industri merupakan strategi yang perlu dilakukan dalam memperluas
diversifikasi produk kopi. Serapan kopi produksi Indonesia berkisar sekitar 35% dan sisanya masih diekspor.
Desa Kaliaren merupakan salah satu desa di Kecamatan Cilimus Kabupaten Kuningan yang wilayahnya
banyak ditanami kopi. Selama ini, penjualaan kopi oleh para petani secara langsung hanya dalam kondisi
segar. Oleh karena itu, perlu dilakukannya suatu usaha untuk memvariasikan produk olahan kopi setempat.
Salah satu usaha tersebut adalah memberdayakan masyarakat agar mampu secara mandiri memanfaatkan
potensi daerahnya yaitu dengan pengetahuan dan keterampilan mengenai wirausaha dan teknologi tepat guna
proses pembuatan sabun scrub kopi yang dapat dijadikan produk souvenir komoditas lokal. Dari hasil
kegiatan yang telah dilakukan dapat ditarik kesimpulan bahwa: (1) Kegiatan PKM ini dapat meningkatkan
motivasi usaha, kesadaran, pengetahuan dan ketrampilan masyarakat melalui penerapan teknologi tepat guna
untuk mengolah komoditas lokal menjadi produk sabun scrub; (2) Peserta pelatihan kelompok ibu-ibu PKK
dan KWT telah mengikuti serangkaian kegiatan pembuatan sabun scrub selanjutnya perlu dikembangkan
kerjasama dengan pihak terkait untuk pengembangan bisnis sabun scrub ke depannya.

Peningkatan serapan kopi oleh industri merupakan strategi yang perlu dilakukan dalam memperluas
diversifikasi produk kopi. Serapan kopi produksi Indonesia berkisar sekitar 35% dan sisanya masih diekspor.
Desa Kaliaren merupakan salah satu desa di Kecamatan Cilimus Kabupaten Kuningan yang wilayahnya
banyak ditanami kopi. Selama ini, penjualaan kopi oleh para petani secara langsung hanya dalam kondisi
segar. Oleh karena itu, perlu dilakukannya suatu usaha untuk memvariasikan produk olahan kopi setempat.
Salah satu usaha tersebut adalah memberdayakan masyarakat agar mampu secara mandiri memanfaatkan
potensi daerahnya yaitu dengan pengetahuan dan keterampilan mengenai wirausaha dan teknologi tepat guna
proses pembuatan sabun scrub kopi yang dapat dijadikan produk souvenir komoditas lokal. Dari hasil
kegiatan yang telah dilakukan dapat ditarik kesimpulan bahwa: (1) Kegiatan PKM ini dapat meningkatkan
motivasi usaha, kesadaran, pengetahuan dan ketrampilan masyarakat melalui penerapan teknologi tepat guna
untuk mengolah komoditas lokal menjadi produk sabun scrub; (2) Peserta pelatihan kelompok ibu-ibu PKK
dan KWT telah mengikuti serangkaian kegiatan pembuatan sabun scrub selanjutnya perlu dikembangkan
kerjasama dengan pihak terkait untuk pengembangan bisnis sabun scrub ke depannya.

The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p 0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.

The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p 0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.

The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p 0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.

The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p 0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.

The research aimed to examine and analyze either partial or simultaneuos influence of brand image, service quality and marketing communication on purchase decision of Mal Artha Gading consumers. Of 40.000 populations, 100 samples were obtained, based on Slovin’s sampling technique. For data collection, the research relied on questionnaires and interviews. Descriptive and inferential statistics were applied for data analysis. The research findings have revealed that brand image, service quality and marketing communication influence consumer purchase decision simultaneously. Partially, brand image variable gave the greatest and the most significant influence on consumer purchase decision, while service quality did not influence consumer purchase decision very much; marketing communication had a significant impact on consumer purchase decision. The implication is that in order to have consumers make a purchase, the management had better improve its brand image, service quality and marketing communication.

The research aimed to examine and analyze either partial or simultaneuos influence of brand image, service quality and marketing communication on purchase decision of Mal Artha Gading consumers. Of 40.000 populations, 100 samples were obtained, based on Slovin’s sampling technique. For data collection, the research relied on questionnaires and interviews. Descriptive and inferential statistics were applied for data analysis. The research findings have revealed that brand image, service quality and marketing communication influence consumer purchase decision simultaneously. Partially, brand image variable gave the greatest and the most significant influence on consumer purchase decision, while service quality did not influence consumer purchase decision very much; marketing communication had a significant impact on consumer purchase decision. The implication is that in order to have consumers make a purchase, the management had better improve its brand image, service quality and marketing communication.